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IRS4 Antikörper (C-Term)

IRS4 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6262669
  • Target Alle IRS4 Antikörper anzeigen
    IRS4 (Insulin Receptor Substrate 4 (IRS4))
    Bindungsspezifität
    • 15
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 32
    • 21
    • 15
    Human
    Wirt
    • 35
    • 2
    • 1
    Kaninchen
    Klonalität
    • 36
    • 2
    Polyklonal
    Konjugat
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser IRS4 Antikörper ist unkonjugiert
    Applikation
    • 26
    • 26
    • 21
    • 10
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    IRS4 Antibody detects endogenous levels of total IRS4.
    Homologie
    Bovine,Horse,Rabbit
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human IRS4, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product IRS4 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    IRS4 (Insulin Receptor Substrate 4 (IRS4))
    Andere Bezeichnung
    IRS4 (IRS4 Produkte)
    Synonyme
    IRS4 antikoerper, irs-4 antikoerper, py160 antikoerper, IRS-4 antikoerper, PY160 antikoerper, irs2 antikoerper, irs2-a antikoerper, insulin receptor substrate 4 antikoerper, insulin receptor substrate 4 S homeolog antikoerper, IRS4 antikoerper, irs4 antikoerper, Irs4 antikoerper, irs4.S antikoerper
    Hintergrund

    Description: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

    Gene: IRS4

    Molekulargewicht
    133 kDa
    Gen-ID
    8471
    UniProt
    O14654
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