IKBKB Antikörper
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- Target Alle IKBKB Antikörper anzeigen
- IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
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Reaktivität
- Human, Maus, Ratte, Affe
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser IKBKB Antikörper ist unkonjugiert
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Applikation
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- IKK-beta Antibody detects endogenous levels of total IKK-beta
- Kreuzreaktivität
- Human, Affe, Maus, Ratte (Rattus)
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human IKK-beta
- Isotyp
- IgG
- Top Product
- Discover our top product IKBKB Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000,IHC 1:50-1:200, IF/ICC 1:100-1:500
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C.Stable for 12 months from date of receipt
- Haltbarkeit
- 12 months
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- Target
- IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
- Andere Bezeichnung
- IKK-beta (IKBKB Produkte)
- Synonyme
- ikk-beta antikoerper, ikk2 antikoerper, ikkb antikoerper, ikkbeta antikoerper, IKBKB antikoerper, IKKB antikoerper, CG4201 antikoerper, DIK antikoerper, DLAK antikoerper, DmIKK antikoerper, DmIKKBeta antikoerper, DmIKKb antikoerper, DmIKKbeta antikoerper, DmIkkbeta antikoerper, Dmel\\CG4201 antikoerper, Dmikkb antikoerper, Dmikkbeta antikoerper, IK antikoerper, IKK antikoerper, IKK-beta antikoerper, IKKb antikoerper, IKKbeta antikoerper, IRD-5 antikoerper, IRD5 antikoerper, Ik antikoerper, Ikkb antikoerper, Ikkbeta antikoerper, Ird-5 antikoerper, Ird5 antikoerper, LRK antikoerper, Lak antikoerper, anon-89Bd antikoerper, dIKK antikoerper, dIKK-beta antikoerper, dIKKbeta antikoerper, dLak antikoerper, dmIKKbeta antikoerper, ikk antikoerper, ird antikoerper, ird5/DmIkk[beta] antikoerper, IKK2 antikoerper, NFKBIKB antikoerper, AIM-1 antikoerper, AI132552 antikoerper, IKK-2 antikoerper, IKK[b] antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog antikoerper, inhibitor of nuclear factor kappa B kinase subunit beta antikoerper, I-kappaB kinase beta antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta antikoerper, inhibitor of kappaB kinase beta antikoerper, ikbkb.L antikoerper, IKBKB antikoerper, ikbkb antikoerper, IKKbeta antikoerper, Ikbkb antikoerper
- Hintergrund
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Description: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Gene: IKBKB
- Molekulargewicht
- 85kDa
- Gen-ID
- 3551
- UniProt
- O14920
- Pathways
- NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine
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