GRB7 Antikörper (Internal Region)
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- Target Alle GRB7 Antikörper anzeigen
- GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GRB7 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- GRB7 Antibody detects endogenous levels of total GRB7.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human GRB7, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product GRB7 Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
- Andere Bezeichnung
- GRB7 (GRB7 Produkte)
- Synonyme
- GRB7 antikoerper, mKIAA4028 antikoerper, growth factor receptor bound protein 7 antikoerper, GRB7 antikoerper, Grb7 antikoerper
- Hintergrund
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Description: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
Gene: GRB7
- Molekulargewicht
- 60 kDa
- Gen-ID
- 2886
- UniProt
- Q14451
- Pathways
- EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization
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