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Golgin A2 (GOLGA2) (N-Term) Antikörper

GOLGA2 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6262002
  • Target Alle Golgin A2 (GOLGA2) Antikörper anzeigen
    Golgin A2 (GOLGA2)
    Bindungsspezifität
    • 15
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 42
    • 26
    • 26
    • 3
    • 2
    Human, Maus, Ratte
    Wirt
    • 32
    • 10
    Kaninchen
    Klonalität
    • 33
    • 9
    Polyklonal
    Konjugat
    • 26
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Unkonjugiert
    Applikation
    • 26
    • 15
    • 13
    • 13
    • 12
    • 12
    • 9
    • 9
    • 6
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    GM130 Antibody detects endogenous levels of total GM130.
    Homologie
    Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human GM130, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product GOLGA2 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IHC 1:200, IF/ICC 1:50-200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    Golgin A2 (GOLGA2)
    Andere Bezeichnung
    GOLGA2 (GOLGA2 Produkte)
    Synonyme
    gm130 antikoerper, MGC81213 antikoerper, AW555139 antikoerper, GM130 antikoerper, mKIAA4150 antikoerper, Gm130 antikoerper, golgin A2 S homeolog antikoerper, golgin A2 antikoerper, golgi autoantigen, golgin subfamily a, 2 antikoerper, golga2.S antikoerper, GOLGA2 antikoerper, Golga2 antikoerper
    Hintergrund

    Description: Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).

    Gene: GOLGA2

    Molekulargewicht
    130 kDa
    Gen-ID
    2801
    UniProt
    Q08379
    Pathways
    SARS-CoV-2 Protein Interaktom
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