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FHIT Antikörper (Internal Region)

FHIT Reaktivität: Human, Maus, Ratte ELISA, WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261742
  • Target Alle FHIT Antikörper anzeigen
    FHIT (Fragile Histidine Triad (FHIT))
    Bindungsspezifität
    • 17
    • 15
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 79
    • 25
    • 11
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 74
    • 10
    Kaninchen
    Klonalität
    • 74
    • 10
    Polyklonal
    Konjugat
    • 35
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser FHIT Antikörper ist unkonjugiert
    Applikation
    • 41
    • 34
    • 26
    • 26
    • 14
    • 10
    • 8
    • 6
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    FHIT Antibody detects endogenous levels of total FHIT.
    Homologie
    Zebrafish,Rabbit,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human FHIT, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product FHIT Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    FHIT (Fragile Histidine Triad (FHIT))
    Andere Bezeichnung
    FHIT (FHIT Produkte)
    Synonyme
    AP3Aase antikoerper, FRA3B antikoerper, FHIT antikoerper, zgc:73176 antikoerper, AW045638 antikoerper, Fra14A2 antikoerper, LOC100223655 antikoerper, fragile histidine triad antikoerper, fragile histidine triad gene antikoerper, fragile histidine triad protein antikoerper, fragile histidine triad L homeolog antikoerper, FHIT antikoerper, Fhit antikoerper, fhit antikoerper, PY07476 antikoerper, fhit.L antikoerper
    Hintergrund

    Description: Cleaves P1-P3-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P1-P4-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P1-P3-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

    Gene: FHIT

    Molekulargewicht
    17kDa
    Gen-ID
    2272
    UniProt
    P49789
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