FANCL Antikörper (Internal Region)

Produktnummer ABIN6261676

Produktdetails anti-FANCL Antikörper

Target: FANCL (Fanconi Anemia, Complementation Group L (FANCL))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: FANCL Antibody detects endogenous levels of total FANCL.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human FANCL, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu FANCL

Target: FANCL (Fanconi Anemia, Complementation Group L (FANCL))

Andere Bezeichnung: FANCL (FANCL Produkte)

Synonyme: FAAP43 antikoerper, PHF9 antikoerper, POG antikoerper, 2010322C19Rik antikoerper, AW554273 antikoerper, B230118H11Rik antikoerper, Phf9 antikoerper, Pog antikoerper, gcd antikoerper, Fanconi anemia complementation group L antikoerper, Fanconi anemia, complementation group L antikoerper, FANCL antikoerper, Fancl antikoerper

Hintergrund:

Description: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.

Gene: FANCL

Molekulargewicht: 43 kDa

Gen-ID: 55120

UniProt: Q9NW38

Pathways: DNA Reparatur