ERCC6 Antikörper (Internal Region)

Produktnummer ABIN6261592

Produktdetails anti-ERCC6 Antikörper

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERCC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: ERCC6 Antibody detects endogenous levels of total ERCC6.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ERCC6, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ERCC6

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Andere Bezeichnung: ERCC6 (ERCC6 Produkte)

Synonyme: ARMD5 antikoerper, CKN2 antikoerper, COFS antikoerper, COFS1 antikoerper, CSB antikoerper, RAD26 antikoerper, UVSS1 antikoerper, 4732403I04 antikoerper, C130058G22Rik antikoerper, ercc6 antikoerper, Ercc6 antikoerper, ERCC excision repair 6, chromatin remodeling factor antikoerper, excision repair cross-complementing rodent repair deficiency, complementation group 6 antikoerper, excision repair cross-complementation group 6 antikoerper, DNA excision repair protein ERCC-6 antikoerper, ERCC6 antikoerper, Ercc6 antikoerper, ercc6 antikoerper, LOC100719487 antikoerper

Hintergrund:

Description: Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.

Gene: ERCC6

Molekulargewicht: 168 kDa

Gen-ID: 2074

UniProt: Q03468

Pathways: DNA Reparatur, Chromatin Binding