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ERAP1 Antikörper (Internal Region)

ERAP1 Reaktivität: Human WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261584
  • Target Alle ERAP1 Antikörper anzeigen
    ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))
    Bindungsspezifität
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 32
    • 17
    • 15
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 30
    • 2
    Kaninchen
    Klonalität
    • 29
    • 3
    Polyklonal
    Konjugat
    • 21
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ERAP1 Antikörper ist unkonjugiert
    Applikation
    • 16
    • 14
    • 10
    • 8
    • 8
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    ERAP1 Antibody detects endogenous levels of total ERAP1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human ERAP1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product ERAP1 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))
    Andere Bezeichnung
    ERAP1 (ERAP1 Produkte)
    Synonyme
    MGC166160 antikoerper, DKFZp469C044 antikoerper, ARTS-1 antikoerper, A-LAP antikoerper, ALAP antikoerper, APPILS antikoerper, ARTS1 antikoerper, ERAAP antikoerper, ERAAP1 antikoerper, PILS-AP antikoerper, PILSAP antikoerper, Arts1 antikoerper, PILSA antikoerper, Appils antikoerper, endoplasmic reticulum aminopeptidase 1 antikoerper, endoplasmic reticulum aminopeptidase 1b antikoerper, ERAP1 antikoerper, erap1 antikoerper, erap1b antikoerper, Erap1 antikoerper
    Hintergrund

    Description: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

    Gene: ERAP1

    Molekulargewicht
    107 kDa
    Gen-ID
    51752
    UniProt
    Q9NZ08
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