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EIF4A3 Antikörper (Internal Region)

EIF4A3 Reaktivität: Human, Maus, Ratte WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261488
  • Target Alle EIF4A3 Antikörper anzeigen
    EIF4A3 (Eukaryotic Translation Initiation Factor 4A3 (EIF4A3))
    Bindungsspezifität
    • 15
    • 14
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 57
    • 33
    • 32
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 56
    • 1
    Kaninchen
    Klonalität
    • 47
    • 10
    Polyklonal
    Konjugat
    • 22
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EIF4A3 Antikörper ist unkonjugiert
    Applikation
    • 45
    • 25
    • 14
    • 14
    • 7
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    EIF4A3 Antibody detects endogenous levels of total eIF4A3.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human eIF4A3, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product EIF4A3 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    EIF4A3 (Eukaryotic Translation Initiation Factor 4A3 (EIF4A3))
    Andere Bezeichnung
    EIF4A3 (EIF4A3 Produkte)
    Synonyme
    DDX48 antikoerper, NMP265 antikoerper, NUK34 antikoerper, eIF4AIII antikoerper, 2400003O03Rik antikoerper, Ddx48 antikoerper, eIF4A-III antikoerper, mKIAA0111 antikoerper, ddx48 antikoerper, nuk34 antikoerper, nmp265 antikoerper, eif4aiii antikoerper, EIF4A3 antikoerper, eif4a3 antikoerper, zgc:56139 antikoerper, XeIF-4AIII antikoerper, eif4a3-B antikoerper, eukaryotic translation initiation factor 4A3 antikoerper, eukaryotic initiation factor 4A-III antikoerper, eukaryotic translation initiation factor 4A3 S homeolog antikoerper, Eukaryotic initiation factor 4A-III antikoerper, EIF4A3 antikoerper, Eif4a3 antikoerper, eif4a3 antikoerper, LOC100185906 antikoerper, eif4a3.S antikoerper, if4a3 antikoerper
    Hintergrund

    Description: ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly (PubMed:22203037). Involved in craniofacial development (PubMed:24360810).

    Gene: EIF4A3

    Molekulargewicht
    47 kDa
    Gen-ID
    9775
    UniProt
    P38919
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