DYRK3 Antikörper (Internal Region)

Produktnummer ABIN6261403

Produktdetails anti-DYRK3 Antikörper

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Bindungsspezifität: Internal Region

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DYRK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: DYRK3 Antibody detects endogenous levels of total DYRK3.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DYRK3, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu DYRK3

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Andere Bezeichnung: DYRK3 (DYRK3 Produkte)

Synonyme: DYRK5 antikoerper, RED antikoerper, REDK antikoerper, hYAK3-2 antikoerper, BC006704 antikoerper, DYRK3 antikoerper, MGC89944 antikoerper, dual specificity tyrosine phosphorylation regulated kinase 3 antikoerper, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 antikoerper, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 antikoerper, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 L homeolog antikoerper, DYRK3 antikoerper, Dyrk3 antikoerper, dyrk3 antikoerper, dyrk3.L antikoerper

Hintergrund:

Description: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). May act by regulating CREB/CRE signaling (By similarity). Stabilizes and prevents stress granule disassembly thereby regulating mTORC1 signaling during cellular stress. During stressful conditions, DYRK3 partitions to the stress granule from the cytosol, as well as mTORC1 components, which prevents mTORC1 signaling. When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol, and promotes the phosphorylation of the mTORC1 inhibitor, AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (PubMed:20167603).

Gene: DYRK3

Molekulargewicht: 66 kDa

Gen-ID: 8444

UniProt: O43781

Pathways: Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha