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DIS3 Antikörper (Internal Region)

DIS3 Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261304
  • Target Alle DIS3 Antikörper anzeigen
    DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))
    Bindungsspezifität
    • 8
    • 8
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 45
    • 16
    • 8
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 40
    • 5
    Kaninchen
    Klonalität
    • 43
    • 2
    Polyklonal
    Konjugat
    • 25
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DIS3 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 22
    • 15
    • 7
    • 6
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    DIS3 Antibody detects endogenous levels of total DIS3.
    Homologie
    Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human DIS3, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product DIS3 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))
    Andere Bezeichnung
    DIS3 (DIS3 Produkte)
    Synonyme
    EXOSC11 antikoerper, KIAA1008 antikoerper, RP11-342J4.3 antikoerper, RRP44 antikoerper, bA555G22.1 antikoerper, dis3p antikoerper, DIS3 antikoerper, 2810028N01Rik antikoerper, RGD1304646 antikoerper, wu:fb08g12 antikoerper, dis3 antikoerper, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease antikoerper, DIS3 exosome endoribonuclease and 3'-5' exoribonuclease antikoerper, DIS3 antikoerper, Dis3 antikoerper, dis3 antikoerper, dis3.L antikoerper
    Hintergrund

    Description: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.

    Gene: DIS3

    Molekulargewicht
    110 kDa
    Gen-ID
    22894
    UniProt
    Q9Y2L1
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