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DDIT4 Antikörper (Internal Region)

DDIT4 Reaktivität: Human, Ratte, Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261248
  • Target Alle DDIT4 Antikörper anzeigen
    DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
    Bindungsspezifität
    • 15
    • 14
    • 13
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 54
    • 23
    • 9
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Ratte, Maus
    Wirt
    • 65
    • 4
    Kaninchen
    Klonalität
    • 67
    • 2
    Polyklonal
    Konjugat
    • 28
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DDIT4 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 33
    • 26
    • 13
    • 13
    • 13
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA
    Spezifität
    DDIT4 Antibody detects endogenous levels of total DDIT4.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human DDIT4, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product DDIT4 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
    Andere Bezeichnung
    DDIT4 (DDIT4 Produkte)
    Synonyme
    redd1 antikoerper, Dig2 antikoerper, REDD-1 antikoerper, REDD1 antikoerper, 5830413E08Rik antikoerper, AA415483 antikoerper, Rtp801 antikoerper, dig2 antikoerper, rtp801 antikoerper, sb:cb821 antikoerper, zgc:64114 antikoerper, DNA damage inducible transcript 4 antikoerper, DNA-damage-inducible transcript 4 antikoerper, DNA damage inducible transcript 4 S homeolog antikoerper, ddit4 antikoerper, DDIT4 antikoerper, Ddit4 antikoerper, ddit4.S antikoerper
    Hintergrund

    Description: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type, it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.

    Gene: DDIT4

    Molekulargewicht
    25 kDa
    Gen-ID
    54541
    UniProt
    Q9NX09
    Pathways
    Neurotrophin Signalübertragung, Regulation of Carbohydrate Metabolic Process
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