DACH1 Antikörper (Internal Region)

Produktnummer ABIN6261216

Produktdetails anti-DACH1 Antikörper

Target: DACH1 (Dachshund 1 (DACH1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DACH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: DACH1 Antibody detects endogenous levels of total DACH1.

Homologie: Pig,Rabbit,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DACH1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu DACH1

Target: DACH1 (Dachshund 1 (DACH1))

Andere Bezeichnung: DACH1 (DACH1 Produkte)

Synonyme: DACH antikoerper, AI182278 antikoerper, Dac antikoerper, Dach antikoerper, E130112M23Rik antikoerper, dach antikoerper, dachshund family transcription factor 1 antikoerper, dachshund 1 (Drosophila) antikoerper, dachshund family transcription factor 1 S homeolog antikoerper, dachshund homolog 1 antikoerper, DACH1 antikoerper, Dach1 antikoerper, dach1.S antikoerper, dach1 antikoerper, LOC100550020 antikoerper

Hintergrund:

Description: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Gene: DACH1

Molekulargewicht: 97-100 kDa

Gen-ID: 1602

UniProt: Q9UI36

Pathways: Feeding Behaviour