COPS5 Antikörper (Internal Region)

Produktnummer ABIN6260970

Produktdetails anti-COPS5 Antikörper

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: COPS5 Antibody detects endogenous levels of total COPS5.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human COPS5, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu COPS5

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Andere Bezeichnung: COPS5 (COPS5 Produkte)

Synonyme: BcDNA.LD14392 antikoerper, BcDNA:LD14392 antikoerper, CG14884 antikoerper, CH5 antikoerper, CSN-5 antikoerper, Csn5 antikoerper, DCH5 antikoerper, Dch5 antikoerper, Dmel\\CG14884 antikoerper, JAB1 antikoerper, JAB1/CSN5 antikoerper, Jab1 antikoerper, JadBp antikoerper, csn5 antikoerper, dch5 antikoerper, jab1/csn5 antikoerper, l(3)89Cf antikoerper, l(3)L4032 antikoerper, l(3)M203 antikoerper, quo antikoerper, COPS5 antikoerper, MGC76063 antikoerper, AI303502 antikoerper, CSN5 antikoerper, Mov34 antikoerper, Sgn5 antikoerper, zgc:73130 antikoerper, MOV-34 antikoerper, SGN5 antikoerper, COP9 signalosome subunit 5 antikoerper, COP9 signalosome complex subunit 5 antikoerper, COP9 signalosome subunit 5 S homeolog antikoerper, CSN5 antikoerper, COPS5 antikoerper, cops5 antikoerper, CpipJ_CPIJ012314 antikoerper, Bm1_46585 antikoerper, VDBG_06932 antikoerper, LOAG_01443 antikoerper, csn5 antikoerper, Cops5 antikoerper, cops5.S antikoerper, csn-5 antikoerper

Hintergrund:

Description: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Gene: COPS5

Molekulargewicht: 37kDa

Gen-ID: 10987

UniProt: Q92905

Pathways: Zellzyklus