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CHMP2A Antikörper (Internal Region)

CHMP2A Reaktivität: Human, Ratte, Maus WB, IHC, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6260811
  • Target Alle CHMP2A Antikörper anzeigen
    CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))
    Bindungsspezifität
    • 15
    • 7
    • 2
    • 2
    Internal Region
    Reaktivität
    • 21
    • 20
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 34
    • 2
    Kaninchen
    Klonalität
    • 36
    Polyklonal
    Konjugat
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CHMP2A Antikörper ist unkonjugiert
    Applikation
    • 27
    • 13
    • 13
    • 11
    • 6
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    CHMP2A Antibody detects endogenous levels of total CHMP2A.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CHMP2A, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))
    Andere Bezeichnung
    CHMP2A (CHMP2A Produkte)
    Synonyme
    BC-2 antikoerper, BC2 antikoerper, CHMP2 antikoerper, VPS2 antikoerper, VPS2A antikoerper, 1500016L11Rik antikoerper, RGD1305050 antikoerper, bc-2 antikoerper, bc2 antikoerper, chmp2 antikoerper, vps2 antikoerper, vps2a antikoerper, fj10d05 antikoerper, wu:fi18h03 antikoerper, wu:fj10d05 antikoerper, zgc:55361 antikoerper, charged multivesicular body protein 2a antikoerper, charged multivesicular body protein 2A antikoerper, Charged multivesicular body protein 2a antikoerper, charged multivesicular body protein 2A L homeolog antikoerper, ATEG_06167 antikoerper, LOC5570080 antikoerper, EDI_289610 antikoerper, PTRG_09933 antikoerper, NAEGRDRAFT_39042 antikoerper, PITG_17335 antikoerper, Tsp_00033 antikoerper, LOC100284170 antikoerper, LOC100284688 antikoerper, chm2a antikoerper, chmp2a antikoerper, CHMP2A antikoerper, Chmp2a antikoerper, chmp2a.L antikoerper
    Hintergrund

    Description: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

    Gene: CHMP2A

    Molekulargewicht
    32 kDa
    Gen-ID
    27243
    UniProt
    O43633
    Pathways
    SARS-CoV-2 Protein Interaktom
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