CASP14 Antikörper (Internal Region)

Produktnummer ABIN6260487

Produktdetails anti-CASP14 Antikörper

Target: CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASP14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Caspase-14 Antibody detects endogenous levels of total Caspase-14.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Caspase-14, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu CASP14

Target: CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))

Andere Bezeichnung: CASP14 (CASP14 Produkte)

Synonyme: CASP14 antikoerper, MICE antikoerper, mini-ICE antikoerper, caspase 14, apoptosis-related cysteine peptidase antikoerper, caspase 14 antikoerper, caspase-14-like antikoerper, caspase-14 antikoerper, CASP14 antikoerper, Casp14 antikoerper, LOC485601 antikoerper, LOC780455 antikoerper

Hintergrund:

Description: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).

Gene: CASP14

Molekulargewicht: 27kDa

Gen-ID: 23581

UniProt: P31944