Caspase 9 Antikörper (Internal Region)

Produktnummer ABIN6260485

Produktdetails anti-Caspase 9 Antikörper

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Caspase 9 Antibody detects endogenous levels of total Caspase 9.

Homologie: Pig,Bovine,Horse,Sheep

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Caspase 9, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Referenzen für anti-Caspase 9 Antikörper (ABIN6260485)

Yuan, Wu, Li, Niu, Tan, Qiu: "Regulation of Signaling Pathways Involved in the Anti-proliferative and Apoptosis-inducing Effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells." in: Scientific reports, Vol. 8, Issue 1, pp. 992, (2018) (PubMed).

Liu, Tang, Liu, Zhang, He, Li, Gao, Tang, Jin, Kong: "Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance." in: Cell death & disease, Vol. 9, Issue 4, pp. 419, (2018) (PubMed).

He, Cao, Guo, Li, Shang, Liu, Xie, Xu, Liu: "Quercetin induces autophagy via FOXO1-dependent pathways and autophagy suppression enhances quercetin-induced apoptosis in PASMCs in hypoxia." in: Free radical biology & medicine, Vol. 103, pp. 165-176, (2017) (PubMed).

Ding, Weng, Fan, Cao, Lu: "Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay." in: Frontiers in molecular neuroscience, Vol. 10, pp. 121, (2017) (PubMed).

Pan, Zhang, Zhao, Zhou, Wang, Deng: "The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway." in: Cancer chemotherapy and pharmacology, Vol. 80, Issue 1, pp. 91-100, (2017) (PubMed).

Details zu Caspase 9

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Andere Bezeichnung: CASP9 (CASP9 Produkte)

Synonyme: CASP9 antikoerper, AI115399 antikoerper, APAF-3 antikoerper, AW493809 antikoerper, CASP-9 antikoerper, Caspase-9 antikoerper, ICE-LAP6 antikoerper, Mch6 antikoerper, Apaf3 antikoerper, Casp-9-CTD antikoerper, Casp9_v1 antikoerper, Ice-Lap6 antikoerper, APAF3 antikoerper, MCH6 antikoerper, PPP1R56 antikoerper, caspase 9 antikoerper, CASP9 antikoerper, Casp9 antikoerper

Hintergrund:

Description: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).

Gene: CASP9

Molekulargewicht: 46kDa

Gen-ID: 842

UniProt: P55211

Pathways: MAPK Signalweg, RTK Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Endopeptidase Activity