Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

BIRC2 Antikörper (C-Term)

BIRC2 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6260268
  • Target Alle BIRC2 Antikörper anzeigen
    BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))
    Bindungsspezifität
    • 7
    • 6
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 42
    • 3
    Kaninchen
    Klonalität
    • 40
    • 5
    Polyklonal
    Konjugat
    • 18
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BIRC2 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 22
    • 21
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    BIRC2 Antibody detects endogenous levels of total BIRC2.
    Homologie
    Bovine,Horse,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human BIRC2, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:400, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))
    Andere Bezeichnung
    BIRC2 (BIRC2 Produkte)
    Synonyme
    API1 antikoerper, HIAP2 antikoerper, Hiap-2 antikoerper, MIHB antikoerper, RNF48 antikoerper, c-IAP1 antikoerper, cIAP1 antikoerper, Api2 antikoerper, rIAP1 antikoerper, IAP1 antikoerper, ITA antikoerper, AW146227 antikoerper, Api1 antikoerper, Birc3 antikoerper, HIAP1 antikoerper, IAP2 antikoerper, MIAP1 antikoerper, MIAP2 antikoerper, MIHC antikoerper, cIAP2 antikoerper, mcIAP1 antikoerper, ciap-1 antikoerper, birc3 antikoerper, api1 antikoerper, birc2 antikoerper, c-iap1 antikoerper, ciap1 antikoerper, hiap-2 antikoerper, hiap2 antikoerper, mihb antikoerper, rnf48 antikoerper, baculoviral IAP repeat containing 2 antikoerper, baculoviral IAP repeat-containing 2 antikoerper, baculoviral IAP repeat containing 2 L homeolog antikoerper, BIRC2 antikoerper, Birc2 antikoerper, birc2 antikoerper, birc2.L antikoerper
    Hintergrund

    Description: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

    Gene: BIRC2

    Molekulargewicht
    70kDa
    Gen-ID
    329
    UniProt
    Q13490
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades
Sie sind hier:
Kundenservice