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BAX Antikörper (Internal Region)

Name: BAX Antikörper (Internal Region)
SKU: ABIN6260204
Price: 698.46 EUR
Availability: InStock

BAX Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

Western blot analysis on HepG2 cell lysate using Bax Antibody.

IF/ICC

2 Abbildungen

(3 Referenzen)

Produktnummer ABIN6260204

Datenblatt (PDF)

Target Alle BAX Antikörper anzeigen

BAX (BCL2-Associated X Protein (BAX))
Bindungsspezifität
41

32

20

18

15

11

10

10

9

8

8

7

6

6

5

4

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Internal Region
Reaktivität
264

158

145

46

31

28

25

18

17

11

9

5

3

3

3

2

1

1

1

1

1
Human, Maus, Ratte
Wirt
170

102

4

2
Kaninchen
Passende Sekundärantikörper
Klonalität
182

96
Polyklonal
Konjugat
148

16

13

13

10

7

7

6

6

6

6

6

5

5

5

5

5

1

1

1

1

1

1

1

1

1
Dieser BAX Antikörper ist unkonjugiert
Applikation
246

114

75

66

55

52

52

48

42

14

12

8

5

3

1

1

1

1

1

1

1

1

1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität

Bax Antibody detects endogenous levels of total Bax.

Homologie

Pig,Bovine,Horse,Rabbit,Dog

Aufreinigung

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen

A synthesized peptide derived from human Bax, corresponding to a region within the internal amino acids.

Isotyp

IgG

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Applikationshinweise

WB: 1:500-1:3000, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit

12 months
Mao, Du, Yang, Zhang, Peng, Jiang, Zhou: "Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 208-214, (2018) (PubMed).

Wang, Li, Li, Pan, Bai, Huang: "Angelicin inhibits liver cancer growth in vitro and in vivo." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 5441-5449, (2018) (PubMed).

Wu, Huang, Jiao, Ding, Zhang, Chen, Wang, Li, Huo: "Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells." in: Oncotarget, Vol. 8, Issue 51, pp. 88630-88644, (2017) (PubMed).
Target

BAX (BCL2-Associated X Protein (BAX))

Andere Bezeichnung

BAX (BAX Produkte)

Synonyme

BAX-ALPHA antikoerper, bax-A antikoerper, xBax antikoerper, xlbax antikoerper, BAX antikoerper, bax antikoerper, fj16e01 antikoerper, wu:fc50b10 antikoerper, wu:fj16e01 antikoerper, BCL2L4 antikoerper, zgc:112983 antikoerper, BCL2 associated X, apoptosis regulator antikoerper, BCL2-associated X protein L homeolog antikoerper, BCL2-associated X protein antikoerper, bcl2-associated X protein, a antikoerper, bcl2-associated X protein, b antikoerper, BAX antikoerper, bax.L antikoerper, bax antikoerper, baxa antikoerper, Bax antikoerper, baxb antikoerper

Hintergrund

Description: Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Gene: BAX

Molekulargewicht

21kDa

Gen-ID

581

UniProt

Q07812

Pathways

p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response