BAG1 Antikörper (N-Term)

Produktnummer ABIN6260189

Produktdetails anti-BAG1 Antikörper

Target: BAG1 (BCL2-Associated Athanogene (BAG1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Bag 1 Antibody detects endogenous levels of total Bag 1.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Bag 1, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu BAG1

Target: BAG1 (BCL2-Associated Athanogene (BAG1))

Andere Bezeichnung: BAG1 (BAG1 Produkte)

Synonyme: BAG-1 antikoerper, HAP antikoerper, RAP46 antikoerper, Rap46 antikoerper, Bag-1 antikoerper, ATBAG1 antikoerper, BCL-2-associated athanogene 1 antikoerper, MSG15.15 antikoerper, MSG15_15 antikoerper, im:7148830 antikoerper, si:dkey-216e9.4 antikoerper, BCL2 associated athanogene 1 antikoerper, putative bcl2-associated athanogene antikoerper, BCL2-associated athanogene 1 antikoerper, Bcl2 associated athanogene 1 antikoerper, BAG family molecular chaperone regulator 1 antikoerper, BCL-2-associated athanogene 1 antikoerper, BAG1 antikoerper, Smp_005900 antikoerper, Bag1 antikoerper, bag-1 antikoerper, LOC781741 antikoerper, bag1 antikoerper

Hintergrund:

Description: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).

Gene: BAG1

Molekulargewicht: 31 kDa

Gen-ID: 573

UniProt: Q99933