Ataxin 3 Antikörper (Internal Region)
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- Target Alle Ataxin 3 (ATXN3) Antikörper anzeigen
- Ataxin 3 (ATXN3)
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Ataxin 3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Spezifität
- Ataxin 3 Antibody detects endogenous levels of total Ataxin 3.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human Ataxin 3, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product ATXN3 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- Ataxin 3 (ATXN3)
- Andere Bezeichnung
- ATXN3 (ATXN3 Produkte)
- Synonyme
- Mjd antikoerper, zgc:56323 antikoerper, ATXN3 antikoerper, at3 antikoerper, jos antikoerper, mjd antikoerper, atx3 antikoerper, mjd1 antikoerper, sca3 antikoerper, ataxin-3 antikoerper, MJD1 antikoerper, MGC83584 antikoerper, AT3 antikoerper, ATX3 antikoerper, JOS antikoerper, MJD antikoerper, SCA3 antikoerper, 2210008M02Rik antikoerper, AI463012 antikoerper, AI647473 antikoerper, Sca3 antikoerper, Rsca3 antikoerper, ataxin 3 antikoerper, ataxin 3 L homeolog antikoerper, ataxin-3 antikoerper, atxn3 antikoerper, ATXN3 antikoerper, atxn3.L antikoerper, MICPUN_104046 antikoerper, MICPUCDRAFT_46658 antikoerper, Atxn3 antikoerper
- Hintergrund
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Description: Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460).
Gene: ATXN3
- Molekulargewicht
- 43kDa
- Gen-ID
- 4287
- UniProt
- P54252
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