ARF1 Antikörper (Internal Region)
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- Target Alle ARF1 Antikörper anzeigen
- ARF1 (ADP-Ribosylation Factor 1 (ARF1))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ARF1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Spezifität
- ARF1 Antibody detects endogenous levels of total ARF1.
- Homologie
- Pig,Zebrafish,Bovine,Sheep,Rabbit,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human ARF1, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product ARF1 Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- ARF1 (ADP-Ribosylation Factor 1 (ARF1))
- Andere Bezeichnung
- ARF1 (ARF1 Produkte)
- Synonyme
- wu:fb33e02 antikoerper, wu:fb78h01 antikoerper, arf2 antikoerper, arf-1 antikoerper, MGC52573 antikoerper, ADP-RIBOSYLATION FACTOR antikoerper, ADP-RIBOSYLATION FACTOR 1A antikoerper, ADP-ribosylation factor 1 antikoerper, ATARF antikoerper, ATARF1 antikoerper, ATARFA1A antikoerper, F28C11.12 antikoerper, ARF1 antikoerper, arf1 antikoerper, ADP ribosylation factor 1 antikoerper, ADP-ribosylation factor 1 antikoerper, ADP ribosylation factor 1 L homeolog antikoerper, ADP ribosylation factor 5 L homeolog antikoerper, ADP ribosylation factor 1 pseudogene antikoerper, adp-ribosylation factor 1 antikoerper, ARF1 antikoerper, Arf1 antikoerper, arf1 antikoerper, arf1.L antikoerper, arf5.L antikoerper, NCU08340 antikoerper, TRIADDRAFT_63238 antikoerper, PAAG_08805 antikoerper, LOC100280562 antikoerper, LOC100280918 antikoerper, LOC474591 antikoerper, CLUG_01013 antikoerper
- Hintergrund
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Description: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Gene: ARF1
- Molekulargewicht
- 20 kDa
- Gen-ID
- 375
- UniProt
- P84077
- Pathways
- Transition Metal Ion Homeostasis, Inositol Metabolic Process
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