ALKBH7 Antikörper
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- Target Alle ALKBH7 Antikörper anzeigen
- ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ALKBH7 Antikörper ist unkonjugiert
- Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Spezifität
- ALKBH7 Antibody detects endogenous levels of total ALKBH7
- Kreuzreaktivität
- Human, Maus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human ALKBH7
- Isotyp
- IgG
- Top Product
- Discover our top product ALKBH7 Primärantikörper
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anti-AlkB, Alkylation Repair Homolog 7 (ALKBH7) (AA 1-221) antibody
ALKBH7 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB 1:1000-3000 IHC 1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C.Stable for 12 months from date of receipt
- Haltbarkeit
- 12 months
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- Target
- ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
- Andere Bezeichnung
- ALKBH7 (ALKBH7 Produkte)
- Synonyme
- ABH7 antikoerper, SPATA11 antikoerper, UNQ6002 antikoerper, 2310045B01Rik antikoerper, 2510008E23Rik antikoerper, Abh7 antikoerper, Spata11 antikoerper, alkB homolog 7 antikoerper, Alkbh7 antikoerper, ALKBH7 antikoerper
- Hintergrund
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Description: May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).
Gene: ALKBH7
- Molekulargewicht
- 24 kDa
- Gen-ID
- 84266
- UniProt
- Q9BT30
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