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SIX Homeobox 1 Antikörper (Internal Region)

SIX1 Reaktivität: Human, Maus WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259572
  • Target Alle SIX Homeobox 1 (SIX1) Antikörper anzeigen
    SIX Homeobox 1 (SIX1)
    Bindungsspezifität
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 29
    • 18
    • 14
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 25
    • 4
    Kaninchen
    Klonalität
    • 26
    • 3
    Polyklonal
    Konjugat
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIX Homeobox 1 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 12
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    SIX1 Antibody detects endogenous levels of total SIX1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SIX1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product SIX1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    SIX Homeobox 1 (SIX1)
    Andere Bezeichnung
    SIX1 (SIX1 Produkte)
    Synonyme
    BOS3 antikoerper, DFNA23 antikoerper, TIP39 antikoerper, BB138287 antikoerper, six1b antikoerper, six2 antikoerper, zgc:92332 antikoerper, XSix1 antikoerper, six1 antikoerper, zgc:77345 antikoerper, SIX homeobox 1 antikoerper, sine oculis-related homeobox 1 antikoerper, SIX homeobox 1a antikoerper, SIX homeobox 1 L homeolog antikoerper, SIX homeobox 1b antikoerper, SIX1 antikoerper, Six1 antikoerper, six1a antikoerper, six1.L antikoerper, six1b antikoerper
    Hintergrund

    Description: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.

    Gene: SIX1

    Molekulargewicht
    33 kDa
    Gen-ID
    6495
    UniProt
    Q15475
    Pathways
    Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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