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RFWD2 Antikörper (Internal Region)

RFWD2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259497
  • Target Alle RFWD2 Antikörper anzeigen
    RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
    Bindungsspezifität
    • 13
    • 10
    • 7
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 48
    • 19
    • 9
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 47
    • 1
    • 1
    Kaninchen
    Klonalität
    • 48
    • 1
    Polyklonal
    Konjugat
    • 27
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RFWD2 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 31
    • 6
    • 4
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    RFWD2 Antibody detects endogenous levels of total RFWD2.
    Homologie
    Bovine,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human RFWD2, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product RFWD2 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
    Andere Bezeichnung
    RFWD2 (RFWD2 Produkte)
    Synonyme
    COP1 antikoerper, RNF200 antikoerper, AI316802 antikoerper, C80879 antikoerper, Cop1 antikoerper, RGD1304773 antikoerper, RFWD2 antikoerper, cop1 antikoerper, rnf200 antikoerper, zgc:163067 antikoerper, ring finger and WD repeat domain 2 antikoerper, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase antikoerper, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog antikoerper, RFWD2 antikoerper, Rfwd2 antikoerper, rfwd2 antikoerper, rfwd2.L antikoerper
    Hintergrund

    Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable).

    Gene: RFWD2

    Molekulargewicht
    80 kDa
    Gen-ID
    64326
    UniProt
    Q8NHY2
    Pathways
    Photoperiodism
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