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RFTN1 Antikörper (Internal Region)

RFTN1 Reaktivität: Human, Maus WB, ELISA, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259466
  • Target Alle RFTN1 Antikörper anzeigen
    RFTN1 (Raftlin, Lipid Raft Linker 1 (RFTN1))
    Bindungsspezifität
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 8
    • 4
    • 3
    • 1
    Human, Maus
    Wirt
    • 9
    Kaninchen
    Klonalität
    • 9
    Polyklonal
    Konjugat
    • 9
    Dieser RFTN1 Antikörper ist unkonjugiert
    Applikation
    • 9
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    RFTN1 Antibody detects endogenous levels of total RFTN1.
    Homologie
    Horse,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human RFTN1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product RFTN1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    RFTN1 (Raftlin, Lipid Raft Linker 1 (RFTN1))
    Andere Bezeichnung
    RFTN1 (RFTN1 Produkte)
    Synonyme
    RAFTLIN antikoerper, RGD1310777 antikoerper, RGD1563347 antikoerper, 2310015n21rik antikoerper, mig2 antikoerper, pig9 antikoerper, pib10 antikoerper, raftlin antikoerper, DKFZp459B0154 antikoerper, 2310015N21Rik antikoerper, AI853526 antikoerper, PIB10 antikoerper, PIG9 antikoerper, raftlin, lipid raft linker 1 antikoerper, raftlin lipid raft linker 1 antikoerper, RFTN1 antikoerper, Rftn1 antikoerper, rftn1 antikoerper
    Hintergrund

    Description: Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216).

    Gene: RFTN1

    Molekulargewicht
    63 kDa
    Gen-ID
    23180
    UniProt
    Q14699
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