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PLK2 Antikörper (Internal Region)

PLK2 Reaktivität: Human, Maus, Ratte WB, ELISA, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259281
  • Target Alle PLK2 Antikörper anzeigen
    PLK2 (Polo-Like Kinase 2 (PLK2))
    Bindungsspezifität
    • 11
    • 8
    • 8
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 56
    • 26
    • 23
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 55
    • 1
    Kaninchen
    Klonalität
    • 56
    Polyklonal
    Konjugat
    • 29
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PLK2 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 36
    • 21
    • 8
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    PLK2 Antibody detects endogenous levels of total PLK2.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human PLK2, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product PLK2 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    PLK2 (Polo-Like Kinase 2 (PLK2))
    Andere Bezeichnung
    PLK2 (PLK2 Produkte)
    Synonyme
    SNK antikoerper, hPlk2 antikoerper, hSNK antikoerper, Snk antikoerper, PLK2 antikoerper, Plx2 antikoerper, MGC53990 antikoerper, plk2 antikoerper, zgc:165644 antikoerper, polo like kinase 2 antikoerper, polo-like kinase 2 antikoerper, polo-like kinase 2 L homeolog antikoerper, polo-like kinase 2b (Drosophila) antikoerper, Serine/threonine-protein kinase plk-2 antikoerper, PLK2 antikoerper, Plk2 antikoerper, plk2.L antikoerper, plk2b antikoerper, plk2 antikoerper, plk-2 antikoerper
    Hintergrund

    Description: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.

    Gene: PLK2

    Molekulargewicht
    78 kDa
    Gen-ID
    10769
    UniProt
    Q9NYY3
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