Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

MAP4K2 Antikörper (Internal Region)

MAP4K2 Reaktivität: Human WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258837
  • Target Alle MAP4K2 Antikörper anzeigen
    MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))
    Bindungsspezifität
    • 12
    • 12
    • 8
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 43
    • 28
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 55
    • 1
    Kaninchen
    Klonalität
    • 56
    Polyklonal
    Konjugat
    • 22
    • 6
    • 6
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAP4K2 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 37
    • 13
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    MAP4K2 Antibody detects endogenous levels of total MAP4K2.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MAP4K2, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product MAP4K2 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))
    Andere Bezeichnung
    MAP4K2 (MAP4K2 Produkte)
    Synonyme
    BL44 antikoerper, GCK antikoerper, RAB8IP antikoerper, AI385662 antikoerper, Rab8ip antikoerper, MAP4K2 antikoerper, dZ150L22.2 antikoerper, map4k2l antikoerper, map4k2l-2 antikoerper, map4k3l antikoerper, si:dz150l22.2 antikoerper, si:dz263j20.1 antikoerper, zgc:136670 antikoerper, mitogen-activated protein kinase kinase kinase kinase 2 antikoerper, mitogen activated protein kinase kinase kinase kinase 2 antikoerper, MAP4K2 antikoerper, Map4k2 antikoerper, LOC103346779 antikoerper, map4k2 antikoerper
    Hintergrund

    Description: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.

    Gene: MAP4K2

    Molekulargewicht
    91 kDa
    Gen-ID
    5871
    UniProt
    Q12851
Sie sind hier:
Kundenservice