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FZD3 Antikörper (Internal Region)

FZD3 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258790
  • Target Alle FZD3 Antikörper anzeigen
    FZD3 (Frizzled Family Receptor 3 (FZD3))
    Bindungsspezifität
    • 15
    • 8
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 59
    • 39
    • 24
    • 15
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 52
    • 4
    • 3
    • 3
    Kaninchen
    Klonalität
    • 56
    • 6
    Polyklonal
    Konjugat
    • 31
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FZD3 Antikörper ist unkonjugiert
    Applikation
    • 57
    • 31
    • 11
    • 10
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    FZD3 Antibody detects endogenous levels of total FZD3.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human FZD3, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product FZD3 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    FZD3 (Frizzled Family Receptor 3 (FZD3))
    Andere Bezeichnung
    FZD3 (FZD3 Produkte)
    Synonyme
    Fz-3 antikoerper, FZ-3 antikoerper, fz3 antikoerper, Xfz3 antikoerper, frz3 antikoerper, hfz3 antikoerper, frz-3 antikoerper, frizzled3 antikoerper, frizzled-3 antikoerper, FZD3 antikoerper, AU020229 antikoerper, D930050A07Rik antikoerper, Fz3 antikoerper, fz9 antikoerper, fzd3 antikoerper, zg09 antikoerper, fzd3l antikoerper, frizzled class receptor 3 antikoerper, frizzled class receptor 3 L homeolog antikoerper, frizzled class receptor 3a antikoerper, frizzled class receptor 3b antikoerper, FZD3 antikoerper, fzd3 antikoerper, fzd3.L antikoerper, Fzd3 antikoerper, fzd3a antikoerper, fzd3b antikoerper
    Hintergrund

    Description: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).

    Gene: FZD3

    Molekulargewicht
    76 kDa
    Gen-ID
    7976
    UniProt
    Q9NPG1
    Pathways
    WNT Signalweg, Tube Formation
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