ARID1B Antikörper (Internal Region)

Produktnummer ABIN6258593

Produktdetails anti-ARID1B Antikörper

Target: ARID1B (AT Rich Interactive Domain 1B (SWI1-Like) (ARID1B))

Bindungsspezifität: Internal Region

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARID1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)

Spezifität: BAF250B Antibody detects endogenous levels of total BAF250B.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BAF250B, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ARID1B

Target: ARID1B (AT Rich Interactive Domain 1B (SWI1-Like) (ARID1B))

Andere Bezeichnung: ARID1B (ARID1B Produkte)

Synonyme: fd07d11 antikoerper, si:dkey-60a16.3 antikoerper, wu:fd07d11 antikoerper, 8030481M12 antikoerper, 9330189K18Rik antikoerper, AI836955 antikoerper, Ardi1b antikoerper, B230217J03Rik antikoerper, mKIAA1235 antikoerper, 6A3-5 antikoerper, Smcf1 antikoerper, smcf-1 antikoerper, BAF250B antikoerper, BRIGHT antikoerper, DAN15 antikoerper, ELD/OSA1 antikoerper, MRD12 antikoerper, OSA2 antikoerper, P250R antikoerper, AT rich interactive domain 1B (SWI1-like) antikoerper, AT rich interactive domain 1B (SWI-like) antikoerper, AT-rich interaction domain 1B antikoerper, arid1b antikoerper, Arid1b antikoerper, ARID1B antikoerper

Hintergrund:

Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388).

Gene: ARID1B

Molekulargewicht: 170 kDa

Gen-ID: 57492

UniProt: Q8NFD5