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Usp30 Antikörper (N-Term)

Usp30 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, IHC, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258562
  • Target Alle Usp30 Antikörper anzeigen
    Usp30 (Ubiquitin Specific Peptidase 30 (Usp30))
    Bindungsspezifität
    • 10
    • 8
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 34
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 33
    • 1
    Kaninchen
    Klonalität
    • 33
    • 1
    Polyklonal
    Konjugat
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Usp30 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 17
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Spezifität
    USP30 Antibody detects endogenous levels of total USP30.
    Homologie
    Pig,Bovine,Horse,Sheep,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human USP30, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    Usp30 (Ubiquitin Specific Peptidase 30 (Usp30))
    Andere Bezeichnung
    USP30 (Usp30 Produkte)
    Synonyme
    6330590F17Rik antikoerper, AI851327 antikoerper, D5Ertd483e antikoerper, si:dkey-72n1.2 antikoerper, ubiquitin specific peptidase 30 antikoerper, ubiquitin specific peptidase 30 L homeolog antikoerper, USP30 antikoerper, usp30 antikoerper, usp30.L antikoerper, Usp30 antikoerper
    Hintergrund

    Description: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).

    Gene: USP30

    Molekulargewicht
    60 kDa
    Gen-ID
    84749
    UniProt
    Q70CQ3
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