CDC42 Antikörper (Internal Region)

Produktnummer ABIN6258461

Produktdetails anti-CDC42 Antikörper

Target: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC42 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Rac1/cdc42 Antibody detects endogenous levels of total Rac1/cdc42.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Rac1/cdc42, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu CDC42

Target: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Andere Bezeichnung: CDC42 (CDC42 Produkte)

Synonyme: CDC42Hs antikoerper, G25K antikoerper, AI747189 antikoerper, AU018915 antikoerper, cdc42a antikoerper, wu:fb07d08 antikoerper, wu:fj62g06 antikoerper, zgc:63918 antikoerper, Xcdc42 antikoerper, cdc42hs antikoerper, g25k antikoerper, CDC42 antikoerper, CG12530 antikoerper, Cdc42Dm antikoerper, D-CDC42 antikoerper, D-Cdc42 antikoerper, D-cdc42 antikoerper, DCDC42 antikoerper, DCdc42 antikoerper, Dcdc42 antikoerper, Dm Cdc42 antikoerper, DmCDC42 antikoerper, Dmcdc42 antikoerper, Dmel\\CG12530 antikoerper, cdc42 antikoerper, cell division cycle 42 antikoerper, Cell division control protein 42 homolog antikoerper, cell division control protein 42 homolog antikoerper, cell division cycle 42 L homeolog antikoerper, CG12530 gene product from transcript CG12530-RC antikoerper, Rho family GTPase antikoerper, CDC42 antikoerper, Cdc42 antikoerper, cdc42 antikoerper, LOC100636735 antikoerper, LOC100637699 antikoerper, LOC100638834 antikoerper, cdc42.L antikoerper

Hintergrund:

Description: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.

Gene: CDC42

Molekulargewicht: ?21 kDa

Gen-ID: 998

UniProt: P60953

Pathways: MAPK Signalweg, Microtubule Dynamics, RTK Signalweg, WNT Signalweg, T-Zell Rezeptor Signalweg, EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2, EGFR Downregulation, VEGF Signaling