POU4F1 Antikörper (Internal Region)

Produktnummer ABIN6258459

Produktdetails anti-POU4F1 Antikörper

Target: POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POU4F1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: POU4F1 Antibody detects endogenous levels of total POU4F1.

Homologie: Pig,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human POU4F1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu POU4F1

Target: POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))

Andere Bezeichnung: POU4F1 (POU4F1 Produkte)

Synonyme: BRN3A antikoerper, Oct-T1 antikoerper, RDC-1 antikoerper, brn-3A antikoerper, POU4F1 antikoerper, Brn-3a antikoerper, Brn-3 antikoerper, Brn-3.0 antikoerper, Brn3 antikoerper, Brn3.0 antikoerper, Brn3a antikoerper, E130119J07Rik antikoerper, brn3.0 antikoerper, brn3a antikoerper, brn3a-A antikoerper, oct-t1 antikoerper, rdc-1 antikoerper, POU class 4 homeobox 1 antikoerper, POU domain, class 4, transcription factor 1 antikoerper, POU class 4 homeobox 1 L homeolog antikoerper, POU4F1 antikoerper, Pou4f1 antikoerper, pou4f1 antikoerper, Tsp_01181 antikoerper, pou4f1.L antikoerper

Hintergrund:

Description: Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.

Gene: POU4F1

Molekulargewicht: 42 kDa

Gen-ID: 5457

UniProt: Q01851

Pathways: Feeding Behaviour