EIF3D Antikörper (Internal Region)

Produktnummer ABIN6258372

Produktdetails anti-EIF3D Antikörper

Target: EIF3D (Eukaryotic Translation Initiation Factor 3, Subunit D (EIF3D))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF3D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: EIF3D Antibody detects endogenous levels of total EIF3D.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EIF3D, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu EIF3D

Target: EIF3D (Eukaryotic Translation Initiation Factor 3, Subunit D (EIF3D))

Andere Bezeichnung: EIF3D (EIF3D Produkte)

Synonyme: eif3s7 antikoerper, eIF3d antikoerper, DDBDRAFT_0217568 antikoerper, DDBDRAFT_0219927 antikoerper, DDB_0217568 antikoerper, DDB_0219927 antikoerper, EIF3S7 antikoerper, An15g03780 antikoerper, AO090026000811 antikoerper, eIF3-p66 antikoerper, eIF3-zeta antikoerper, 66/67kDa antikoerper, AA407891 antikoerper, Eif3s7 antikoerper, eIF3p66 antikoerper, wu:fb12a03 antikoerper, zgc:64097 antikoerper, eukaryotic translation initiation factor 3 subunit D antikoerper, eukaryotic translation initiation factor 3 subunit 7 antikoerper, eukaryotic initiation factor antikoerper, eIF-3 zeta antikoerper, eukaryotic translation initiation factor 3, subunit D antikoerper, translation initiation factor eIF-3 subunit 7 antikoerper, eukaryotic translation initiation factor 3 subunit D S homeolog antikoerper, Eukaryotic translation initiation factor 3 subunit D antikoerper, eif3d antikoerper, EIF3D antikoerper, eIF3-S7 antikoerper, ANI_1_540134 antikoerper, AOR_1_1456014 antikoerper, PTRG_07832 antikoerper, VDBG_06053 antikoerper, PGTG_10613 antikoerper, Tsp_00484 antikoerper, Eif3d antikoerper, eif3d.S antikoerper, eif-3.D antikoerper

Hintergrund:

Description: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).

Gene: EIF3D

Molekulargewicht: 64 kDa

Gen-ID: 8664

UniProt: O15371

Pathways: Ribonucleoprotein Complex Subunit Organization