USP19 Antikörper (Internal Region)

Produktnummer ABIN6258348

Produktdetails anti-USP19 Antikörper

Target: USP19 (Ubiquitin Specific Peptidase 19 (USP19))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: USP19 Antibody detects endogenous levels of total USP19.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human USP19, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu USP19

Target: USP19 (Ubiquitin Specific Peptidase 19 (USP19))

Andere Bezeichnung: USP19 (USP19 Produkte)

Synonyme: wu:fc26a05 antikoerper, si:dkey-32e6.9 antikoerper, USP19 antikoerper, MGC145127 antikoerper, ZMYND9 antikoerper, 8430421I07Rik antikoerper, AI047774 antikoerper, Zmynd9 antikoerper, ubiquitin specific peptidase 19 antikoerper, universal stress protein antikoerper, ubiquitin carboxyl-terminal hydrolase 19 antikoerper, usp19 antikoerper, USP19 antikoerper, RR_RS18085 antikoerper, PTRG_09611 antikoerper, Usp19 antikoerper

Hintergrund:

Description: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains.

Gene: USP19

Molekulargewicht: 130 kDa

Gen-ID: 10869

UniProt: O94966