MARK1 Antikörper

Produktnummer ABIN6258271

Produktdetails anti-MARK1 Antikörper

Target: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: MARK Antibody detects endogenous levels of total MARK

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu MARK1

Target: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Andere Bezeichnung: MARK (MARK1 Produkte)

Synonyme: MGC80341 antikoerper, MARK1 antikoerper, AW491150 antikoerper, B930025N23Rik antikoerper, Emk3 antikoerper, Par-1c antikoerper, mKIAA1477 antikoerper, mPar-1c antikoerper, MARK antikoerper, Par1c antikoerper, MAP/microtubule affinity-regulating kinase 1 S homeolog antikoerper, microtubule affinity regulating kinase 1 antikoerper, MAP/microtubule affinity-regulating kinase 1 antikoerper, MAP/microtubule affinity regulating kinase 1 antikoerper, mark1.S antikoerper, MARK1 antikoerper, mark1 antikoerper, Mark1 antikoerper

Hintergrund:

Description: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Gene: MARK1

Molekulargewicht: 89 kDa

Gen-ID: 4139

UniProt: Q9P0L2, Q7KZI7, P27448, Q96L34

Pathways: SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion