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RAD1 Antikörper (Internal Region)

RAD1 Reaktivität: Human, Maus WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6257451
  • Target Alle RAD1 Antikörper anzeigen
    RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))
    Bindungsspezifität
    • 7
    • 7
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 33
    • 12
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 29
    • 4
    • 1
    Kaninchen
    Klonalität
    • 32
    • 2
    Polyklonal
    Konjugat
    • 17
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RAD1 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 17
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    RAD1 Antibody detects endogenous levels of total RAD1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human RAD1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product RAD1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))
    Andere Bezeichnung
    RAD1 (RAD1 Produkte)
    Synonyme
    HRAD1 antikoerper, REC1 antikoerper, zgc:56502 antikoerper, zgc:77779 antikoerper, RAD1 antikoerper, xrad1 antikoerper, DKFZp459H1127 antikoerper, RAD1 checkpoint DNA exonuclease antikoerper, RAD1 homolog (S. pombe) antikoerper, RAD1 antikoerper, Rad1 antikoerper, rad1 antikoerper
    Hintergrund

    Description: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799).

    Gene: RAD1

    Molekulargewicht
    32 kDa
    Gen-ID
    5810
    UniProt
    O60671
    Pathways
    M Phase
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