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Topoisomerase I Antikörper (Internal Region)

TOP1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6257133
  • Target Alle Topoisomerase I (TOP1) Antikörper anzeigen
    Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))
    Bindungsspezifität
    • 11
    • 11
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 66
    • 24
    • 13
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 53
    • 11
    • 2
    Kaninchen
    Klonalität
    • 43
    • 23
    Polyklonal
    Konjugat
    • 36
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Topoisomerase I Antikörper ist unkonjugiert
    Applikation
    • 42
    • 19
    • 19
    • 13
    • 8
    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    TOP1 Antibody detects endogenous levels of total TOP1.
    Homologie
    Pig,Zebrafish,Horse,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human TOP1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product TOP1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))
    Andere Bezeichnung
    TOP1 (TOP1 Produkte)
    Synonyme
    CG6146 antikoerper, Dmel\\CG6146 antikoerper, TOP1 antikoerper, TopI antikoerper, Topo I antikoerper, TopoI antikoerper, dTopoI antikoerper, l(1)G0134 antikoerper, l(1)G0201 antikoerper, l(1)G0229 antikoerper, l(1)G0278 antikoerper, l(1)top1 antikoerper, top1 antikoerper, topo I antikoerper, topoI antikoerper, DNA topoisomerase 1 beta antikoerper, DNA topoisomerase I alpha antikoerper, MGO1 antikoerper, MGOUN 1 antikoerper, MTE17.1 antikoerper, MTE17_1 antikoerper, TOP1BETA antikoerper, TOPOISOMERASE 1 antikoerper, TOPI antikoerper, AI467334 antikoerper, D130064I21Rik antikoerper, Top-1 antikoerper, Ab2-086 antikoerper, topi antikoerper, Topoisomerase 1 antikoerper, DNA topoisomerase I antikoerper, DNA topoisomerase I alpha antikoerper, DNA topoisomerase 1 antikoerper, topoisomerase (DNA) I antikoerper, DNA topoisomerase I, gene 1 L homeolog antikoerper, Top1 antikoerper, top1 antikoerper, topA antikoerper, ZMO1193 antikoerper, MRAD2831_RS63095 antikoerper, Lferr_0016 antikoerper, PC1_2015 antikoerper, Za10_0136 antikoerper, Gbro_0575 antikoerper, Dd586_2108 antikoerper, Kvar_3044 antikoerper, Alvin_2069 antikoerper, Dacet_0849 antikoerper, Mrub_1615 antikoerper, Arnit_2962 antikoerper, Ndas_4953 antikoerper, Trad_2377 antikoerper, Acear_1653 antikoerper, Mahau_0844 antikoerper, Mesop_4109 antikoerper, Thein_1586 antikoerper, Theth_0241 antikoerper, TOP1ALPHA antikoerper, top-1 antikoerper, TOP1 antikoerper, top1.1.L antikoerper
    Substanzklasse
    Viral Protein
    Hintergrund

    Description: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.

    Gene: TOP1

    Molekulargewicht
    90 kDa
    Gen-ID
    7150
    UniProt
    P11387
    Pathways
    Caspase Kaskade in der Apoptose, Stem Cell Maintenance
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