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PI3K p85 alpha/gamma Antikörper (pTyr199, pTyr467)

PI3K p85a/g Reaktivität: Human, Maus, Ratte, Affe WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6256668
  • Target Alle PI3K p85 alpha/gamma (PI3K p85a/g) Produkte
    PI3K p85 alpha/gamma (PI3K p85a/g) (Phosphoinositide 3 Kinase, p85 alpha/gamma (PI3K p85a/g))
    Bindungsspezifität
    • 17
    • 17
    • 1
    • 1
    • 1
    pTyr199, pTyr467
    Reaktivität
    • 21
    • 21
    • 21
    • 16
    • 4
    • 1
    Human, Maus, Ratte, Affe
    Wirt
    • 21
    Kaninchen
    Klonalität
    • 21
    Polyklonal
    Konjugat
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PI3K p85 alpha/gamma Antikörper ist unkonjugiert
    Applikation
    • 21
    • 14
    • 13
    • 13
    • 8
    • 5
    • 5
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Phospho-PI3-kinase p85- alpha/ gamma (Tyr467/199) Antibody detects endogenous levels of PI3-kinase p85- alpha/ gamma only when phosphorylated at Tyrosine 467/199
    Kreuzreaktivität
    Human, Affe, Maus, Ratte (Rattus)
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human PI3-kinase p85- alpha/ gamma around the phosphorylation site of Tyrosine 467/199
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000 IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C.Stable for 12 months from date of receipt
    Haltbarkeit
    12 months
  • Wang, Li, Li, Pan, Bai, Huang: "Angelicin inhibits liver cancer growth in vitro and in vivo." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 5441-5449, (2018) (PubMed).

  • Target
    PI3K p85 alpha/gamma (PI3K p85a/g) (Phosphoinositide 3 Kinase, p85 alpha/gamma (PI3K p85a/g))
    Andere Bezeichnung
    PI3-kinase p85 alpha/ gamma (PI3K p85a/g Produkte)
    Hintergrund

    Description: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

    Gene: PIK3R1

    Molekulargewicht
    54,83kDa
    Gen-ID
    5295
    UniProt
    P27986, Q92569
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