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NFKB1 Antikörper (pSer337)

NFKB1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6256276
  • Target Alle NFKB1 Antikörper anzeigen
    NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))
    Bindungsspezifität
    • 34
    • 29
    • 28
    • 28
    • 16
    • 16
    • 16
    • 16
    • 15
    • 13
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer337
    Reaktivität
    • 321
    • 176
    • 153
    • 11
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 318
    • 21
    • 1
    • 1
    Kaninchen
    Klonalität
    • 313
    • 28
    Polyklonal
    Konjugat
    • 141
    • 21
    • 16
    • 16
    • 16
    • 16
    • 16
    • 16
    • 15
    • 12
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 2
    Dieser NFKB1 Antikörper ist unkonjugiert
    Applikation
    • 180
    • 118
    • 118
    • 104
    • 103
    • 67
    • 62
    • 35
    • 28
    • 14
    • 11
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Phospho-NF kappaB p105/p50 (Ser337) Antibody detects endogenous levels of NF kappaB p105/p50 only when phosphorylated at Serine 337.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human NF- kappaB p105/p50 around the phosphorylation site of Ser337.
    Isotyp
    IgG
    Top Product
    Discover our top product NFKB1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))
    Andere Bezeichnung
    NFKB1 (NFKB1 Produkte)
    Synonyme
    GKLP antikoerper, NKTL antikoerper, NTKL antikoerper, P105 antikoerper, TAPK antikoerper, TEIF antikoerper, TRAP antikoerper, EBP-1 antikoerper, KBF1 antikoerper, NF-kB1 antikoerper, NF-kappa-B antikoerper, NF-kappaB antikoerper, NFKB-p105 antikoerper, NFKB-p50 antikoerper, NFkappaB antikoerper, p105 antikoerper, p50 antikoerper, NF-kB antikoerper, NF-KB1 antikoerper, ebp-1 antikoerper, kbf1 antikoerper, nf-kappa-b antikoerper, nf-kappaB antikoerper, nfkb-p105 antikoerper, nfkb-p50 antikoerper, NF-kappaB1 antikoerper, p50/p105 antikoerper, BICDR-1 antikoerper, bicdr1 antikoerper, ccdc64 antikoerper, SCY1 like pseudokinase 1 antikoerper, nuclear factor kappa B subunit 1 antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog antikoerper, nuclear factor NF-kappa-B p105 subunit antikoerper, nucleoporin 107 antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 antikoerper, SCYL1 antikoerper, NFKB1 antikoerper, Nfkb1 antikoerper, nfkb1.L antikoerper, CpipJ_CPIJ012236 antikoerper, Nup107 antikoerper, nfkb1 antikoerper
    Hintergrund

    Description: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling, active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

    Gene: NFKB1

    Molekulargewicht
    105,50kDa
    Gen-ID
    4790
    UniProt
    P19838
    Pathways
    p53 Signalweg, NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteine
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