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ATR Antikörper (pSer428)

ATR Reaktivität: Human, Maus, Ratte ELISA, WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6255330
  • Target Alle ATR Antikörper anzeigen
    ATR (ATR serine/threonine kinase (ATR))
    Bindungsspezifität
    • 10
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer428
    Reaktivität
    • 46
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 40
    • 5
    • 2
    Kaninchen
    Klonalität
    • 43
    • 4
    Polyklonal
    Konjugat
    • 31
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ATR Antikörper ist unkonjugiert
    Applikation
    • 25
    • 22
    • 18
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    Phospho -ATR(S428) Antibody detects endogenous levels of ATR only when phosphorylated at S428
    Kreuzreaktivität
    Human, Maus, Ratte (Rattus)
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human phospho -ATR(S428)
    Isotyp
    IgG
    Top Product
    Discover our top product ATR Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000 IHC 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C.Stable for 12 months from date of receipt
    Haltbarkeit
    12 months
  • Target
    ATR (ATR serine/threonine kinase (ATR))
    Andere Bezeichnung
    ATR (ATR Produkte)
    Synonyme
    FCTCS antikoerper, FRP1 antikoerper, MEC1 antikoerper, SCKL antikoerper, SCKL1 antikoerper, ATR serine/threonine kinase antikoerper, ataxia telangiectasia and Rad3 related antikoerper, ATR antikoerper, Atr antikoerper
    Hintergrund

    Description: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

    Gene: ATR

    Molekulargewicht
    300 kDa
    Gen-ID
    545
    UniProt
    Q13535
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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