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CTR9 Antikörper (C-Term)

CTR9 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB50966 unconjugated
Produktnummer ABIN6243850
  • Target Alle CTR9 Antikörper anzeigen
    CTR9 (RNA Polymerase-Associated Protein CTR9 Homolog (CTR9))
    Bindungsspezifität
    • 15
    • 4
    • 3
    • 2
    • 1
    • 1
    AA 1022-1056, C-Term
    Reaktivität
    • 27
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 27
    Kaninchen
    Klonalität
    • 27
    Polyklonal
    Konjugat
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CTR9 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 13
    • 13
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Mouse Ctr9 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1022-1056 amino acids from the C-terminal region of human Mouse Ctr9.
    Klon
    RB50966
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product CTR9 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    CTR9 (RNA Polymerase-Associated Protein CTR9 Homolog (CTR9))
    Andere Bezeichnung
    Ctr9 (CTR9 Produkte)
    Synonyme
    SH2BP1 antikoerper, TSBP antikoerper, p150 antikoerper, p150TSP antikoerper, AA409336 antikoerper, Sh2bp1 antikoerper, Tsbp antikoerper, Tsp antikoerper, mKIAA0155 antikoerper, sh2bp1 antikoerper, p150tsp antikoerper, tsbp antikoerper, fc54a06 antikoerper, wu:fc54a06 antikoerper, CTR9 homolog, Paf1/RNA polymerase II complex component antikoerper, CTR9 homolog, Paf1/RNA polymerase II complex component S homeolog antikoerper, Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) antikoerper, RNA polymerase-associated protein CTR9 homolog antikoerper, CTR9 antikoerper, Ctr9 antikoerper, ctr9.S antikoerper, ctr9 antikoerper, LOC100161197 antikoerper, LOC100163982 antikoerper, LOC100168634 antikoerper, LOC100478349 antikoerper, LOC100543206 antikoerper, LOC100645071 antikoerper
    Hintergrund
    Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys- 4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys- 4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription (By similarity). Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency, this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway, may regulate DNA-association of STAT3.
    Molekulargewicht
    133408
    UniProt
    Q62018
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance
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