DOT1L Antikörper (C-Term)

Produktnummer ABIN6243177

Produktdetails anti-DOT1L Antikörper

Target: DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))

Bindungsspezifität: AA 1390-1420, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOT1L Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This KMT4 / Dot1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1390~1420 amino acids from the C-terminal region of human DOT1L.

Klon: RB2773

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-DOT1L Antikörper (ABIN6243177)

Nguyen, Xiao, Neppl, Kallin, Li, Chen, Wang, Xiao, Zhang: "DOT1L regulates dystrophin expression and is critical for cardiac function." in: Genes & development, Vol. 25, Issue 3, pp. 263-74, (2011) (PubMed).

Comty, Wathen, Shapiro: "Uremic pericarditis." in: Cardiovascular clinics, Vol. 7, Issue 3, pp. 219-35, (1977) (PubMed).

Details zu DOT1L

Target: DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))

Andere Bezeichnung: KMT4 / Dot1L (DOT1L Produkte)

Synonyme: NV11307 antikoerper, DOT1L antikoerper, DOT1 antikoerper, KMT4 antikoerper, A630076O07 antikoerper, AW907654 antikoerper, Dot1 antikoerper, mDot1 antikoerper, histone-lysine N-methyltransferase, H3 lysine-79 specific antikoerper, DOT1 like histone lysine methyltransferase antikoerper, histone methyltransferase antikoerper, DOT1-like, histone H3 methyltransferase (S. cerevisiae) antikoerper, LOC100116648 antikoerper, DOT1L antikoerper, DOT1 antikoerper, Dot1l antikoerper

Hintergrund: Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

Molekulargewicht: 164856

NCBI Accession: NP_115871

UniProt: Q8TEK3