SMARCE1 Antikörper (C-Term)

Produktnummer ABIN6242198

Produktdetails anti-SMARCE1 Antikörper

Target: SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily E, Member 1 (SMARCE1))

Bindungsspezifität: AA 327-361, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMARCE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SMARCE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 327-361 amino acids from the C-terminal region of human SMARCE1.

Klon: RB51409

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu SMARCE1

Target: SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily E, Member 1 (SMARCE1))

Andere Bezeichnung: SMARCE1 (SMARCE1 Produkte)

Synonyme: BAF57 antikoerper, XBaf57 antikoerper, MGC52696 antikoerper, MGC69429 antikoerper, MGC81726 antikoerper, SMARCE1 antikoerper, DKFZp459O2235 antikoerper, fb54d11 antikoerper, wu:fb33d02 antikoerper, wu:fb54d11 antikoerper, Baf57 antikoerper, 2810417B20Rik antikoerper, 5830412H02Rik antikoerper, 9030408N19Rik antikoerper, Baf27 antikoerper, RGD1304726 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 L homeolog antikoerper, smarce1 antikoerper, SMARCE1 antikoerper, smarce1.L antikoerper, Smarce1 antikoerper

Hintergrund: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Molekulargewicht: 46649

UniProt: Q969G3

Pathways: Chromatin Binding