COL17A1 Antikörper (Chain alpha 1)

Produktnummer ABIN615636

Produktdetails anti-COL17A1 Antikörper

Target: COL17A1 (Collagen, Type XVII, alpha 1 (COL17A1))

Bindungsspezifität: Chain alpha 1

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COL17A1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: Recognizes Mouse Collagen type XVII

Aufreinigung: Ig Fraction

Immunogen: Mouse COL17A Genename: Col17a1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in aqua bidest to initial volume

Buffer: PBS pH 7.4

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8 °C and reconstituted at -20 °C.

Details zu COL17A1

Target: COL17A1 (Collagen, Type XVII, alpha 1 (COL17A1))

Abstract: COL17A1 Produkte

Synonyme: col17a1 antikoerper, fk89a06 antikoerper, si:ch211-223p8.6 antikoerper, wu:fk89a06 antikoerper, COL17A1 antikoerper, BA16H23.2 antikoerper, BP180 antikoerper, BPA-2 antikoerper, BPAG2 antikoerper, LAD-1 antikoerper, Bpag antikoerper, Bpag2 antikoerper, collagen type XVII alpha 1 chain antikoerper, collagen, type XVII, alpha 1b antikoerper, collagen, type XVII, alpha 1 antikoerper, Col17a1 antikoerper, col17a1b antikoerper, COL17A1 antikoerper

Hintergrund: Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in the gene coding for collagen XVII are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD 1, is generated by proteolytic processing of the full length form. Two transcript variants, one resulting from alternative splicing in the 3' UTR, have been identified for this gene.Synonyms: 180 kDa bullous pemphigoid antigen 2, BP180, BPAG2, Bullous pemphigoid antigen 2, COL17A1, LABD97, LAD-1

Gen-ID: 12821

NCBI Accession: NP_031758

UniProt: Q07563