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eIF4EBP2 Antikörper (AA 99-120)

EIF4EBP2 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN615304
  • Target Alle eIF4EBP2 (EIF4EBP2) Antikörper anzeigen
    eIF4EBP2 (EIF4EBP2) (Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))
    Bindungsspezifität
    • 15
    • 14
    • 7
    • 7
    • 3
    • 2
    • 1
    • 1
    AA 99-120
    Reaktivität
    • 48
    • 7
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 45
    • 3
    Kaninchen
    Klonalität
    • 46
    • 2
    Polyklonal
    Konjugat
    • 18
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser eIF4EBP2 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 28
    • 13
    • 13
    • 10
    • 6
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    Detects 17 and 20 kDa proteins, corresponding to the apparent molecular mass of PHAS-II and its phosphorylated state on SDS-PAGE immunoblots.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Bovine, Canine, Porcine, Mouse and Rat.
    Species reactivity (tested):Human.
    Aufreinigung
    Immunoaffinity Chromatography
    Immunogen
    EIF4EBP2 antibody was raised against human PHAS-II synthetic peptide (residues 99-120) was synthesized and the peptide coupled to KLH. .Remarks: This sequence is 96% homologous to mouse PHAS-11 over these residues
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  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1,0 mg/mL
    Buffer
    BBS, pH 8.4 (25 mM sodium borate, 100 mM boric acid, 75 mM sodium chloride, 5 mM EDTA)
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    eIF4EBP2 (EIF4EBP2) (Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))
    Andere Bezeichnung
    4E-BP2 (EIF4EBP2 Produkte)
    Synonyme
    4ebp2 antikoerper, MGC75579 antikoerper, wu:fa55e11 antikoerper, wu:fp45e09 antikoerper, MGC78987 antikoerper, EIF4EBP2 antikoerper, eIF-4E antikoerper, Tb06.28P18.1010 antikoerper, 4EBP2 antikoerper, PHASII antikoerper, 2810011I19Rik antikoerper, 4E-BP2 antikoerper, AA792569 antikoerper, BC010348 antikoerper, PHAS-II antikoerper, eukaryotic translation initiation factor 4E binding protein 2 antikoerper, eukaryotic translation initiation factor 4E binding protein 2 L homeolog antikoerper, eukaryotic initiation factor 4E antikoerper, eukaryotic translation initiation factor 4E antikoerper, putative eukaryotic translation initiation factor 4e antikoerper, eif4ebp2 antikoerper, Eif4ebp2 antikoerper, eif4ebp2.L antikoerper, EIF4EBP2 antikoerper, eIF-4E antikoerper, Tb927.6.1870 antikoerper, LMJF_30_0450 antikoerper
    Hintergrund
    PHAS-II, also known as eIF4E-binding protein II (eIF4E-BPII), is a member of a family of proteins which regulate initiation. PHAS-I and -II were found to have overlapping but different patterns of expression in tissues. PHAS-II shows the highest expression in liver and kidney where very little PHAS-I is found. The PHAS proteins regulate translation initiation by binding to the inhibitory protein eIF- 4E and blocking translation by preventing access of eIF-4G to the 5' cap of the mRNA. Both PHAS proteins are phosphorylated in response to insulin or growth factors such as EGF, PDGF and IGF-1. Phosphorylation in the appropriate site(s) promotes dissociation of PHAS/eIF-4E complexes which allows eIF-4E to bind eIF-4G(p220), thereby increasing the amount of eIF-4F complex and the rate of translation initiation. Regulation of the two protein differ because PHAS-II, unlike PHAS-I is readily phosphorylated by PKA in vitro. However increasing cAMP in cells promotes dephosphorylation of both PHAS-I and PHAS-II. Pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway is involved in the control of PHAS-I and -II suggesting that these proteins may be mediators of the effects of this pathway on protein synthesis and cell proliferation.Synonyms: EIF4EBP2, Eukaryotic translation initiation factor 4E-binding protein 2, eIF4E-binding protein 2
    Gen-ID
    1979
    NCBI Accession
    NP_004087
    UniProt
    Q13542
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