UQCRFS1 Antikörper (AA 79-274)

Produktnummer ABIN6149963

Produktdetails anti-UQCRFS1 Antikörper

Target: UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 (UQCRFS1))

Bindungsspezifität: AA 79-274

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UQCRFS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: SHTDIKVPDF SEYRRLEVLD STKSSRESSE ARKGFSYLVT GVTTVGVAYA AKNAVTQFVS SMSASADVLA LAKIEIKLSD IPEGKNMAFK WRGKPLFVRH RTQKEIEQEA AVELSQLRDP QHDLDRVKKP EWVILIGVCT HLGCVPIANA GDFGGYYCPC HGSHYDASGR IRLGPAPLNL EVPTYEFTSD DMVIVG

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 79-274 of human UQCRFS1 (NP_005994.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-UQCRFS1 Antikörper (ABIN6149963)

Hu, Nie, Chen, Xie, Fan, Wang, Long, Yan, Zhong, Yan: "Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells." in: The international journal of biochemistry & cell biology, Vol. 89, pp. 42-56, (2017) (PubMed).

Details zu UQCRFS1

Target: UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 (UQCRFS1))

Andere Bezeichnung: UQCRFS1 (UQCRFS1 Produkte)

Synonyme: uqcrfs1 antikoerper, MGC53134 antikoerper, rip1 antikoerper, ris1 antikoerper, risp antikoerper, uqcr5 antikoerper, fb78f10 antikoerper, wu:fb05d11 antikoerper, wu:fb78f10 antikoerper, wu:fj05e12 antikoerper, zgc:73109 antikoerper, zgc:85614 antikoerper, GLEAN_00043 antikoerper, RIP1 antikoerper, RIS1 antikoerper, RISP antikoerper, UQCR5 antikoerper, 4430402G14Rik antikoerper, AI875505 antikoerper, LRRGT00195 antikoerper, UQCRFSL1 antikoerper, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 S homeolog antikoerper, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 antikoerper, cytochrome b-c1 complex subunit Rieske, mitochondrial antikoerper, iron-sulfur protein 1 antikoerper, uqcrfs1.S antikoerper, uqcrfs1 antikoerper, LOC661125 antikoerper, LOC705178 antikoerper, UQCRFS1 antikoerper, Uqcrfs1 antikoerper, LOC100227575 antikoerper, isp1 antikoerper

Hintergrund: [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII, ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII and cytochrome c oxidase (complex IV, CIV, that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0 site in cytochrome b to cytochrome c1 (By similarity. Incorporation of UQCRFS1 is the penultimate step in complex III assembly.,UQCRFS1,RIP1,RIS1,RISP,UQCR5,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Oxidative phosphorylation,Neuroscience,Neurodegenerative Diseases,UQCRFS1

Molekulargewicht: 29 kDa

Gen-ID: 7386

UniProt: P47985

Pathways: Proton Transport