TAB1 Antikörper (AA 205-504)

Produktnummer ABIN6148795

Produktdetails anti-TAB1 Antikörper

Target: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Bindungsspezifität: AA 205-504

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Sequenz: VDHTTENEDE LFRLSQLGLD AGKIKQVGII CGQESTRRIG DYKVKYGYTD IDLLSAAKSK PIIAEPEIHG AQPLDGVTGF LVLMSEGLYK ALEAAHGPGQ ANQEIAAMID TEFAKQTSLD AVAQAVVDRV KRIHSDTFAS GGERARFCPR HEDMTLLVRN FGYPLGEMSQ PTPSPAPAAG GRVYPVSVPY SSAQSTSKTS VTLSLVMPSQ GQMVNGAHSA STLDEATPTL TNQSPTLTLQ STNTHTQSSS SSSDGGLFRS RPAHSLPPGE DGRVEPYVDF AEFYRLWSVD HGEQSVVTAP

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 205-504 of human TAB1 (NP_006107.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:10 - 1:100,IP,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TAB1

Target: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Andere Bezeichnung: TAB1 (TAB1 Produkte)

Synonyme: 3'-Tab1 antikoerper, MAP3K7IP1 antikoerper, 2310012M03Rik antikoerper, Map3k7ip1 antikoerper, b2b449Clo antikoerper, TGF-beta activated kinase 1 (MAP3K7) binding protein 1 antikoerper, TGF-beta activated kinase 1/MAP3K7 binding protein 1 antikoerper, TAB1 antikoerper, Tab1 antikoerper

Hintergrund: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.,TAB1,3'-Tab1,MAP3K7IP1,Signal Transduction,Kinase,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Wnt/β-Catenin Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TLR Signaling,Cardiovascular,TAB1

Molekulargewicht: 49 kDa/54 kDa

Gen-ID: 10454

UniProt: Q15750

Pathways: TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades