ROBO4 Antikörper (AA 848-1007)

Produktnummer ABIN6147063

Produktdetails anti-ROBO4 Antikörper

Target: ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (ROBO4))

Bindungsspezifität: AA 848-1007

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROBO4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GVGPKGGVLL CPPRPCLTPT PSEGSLANGW GSASEDNAAS ARASLVSSSD GSFLADAHFA RALAVAVDSF GFGLEPREAD CVFIDASSPP SPRDEIFLTP NLSLPLWEWR PDWLEDMEVS HTQRLGRGMP PWPPDSQISS QRSQLHCRMP KAGASPVDYS

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 848-1007 of human ROBO4 (NP_061928.4).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ROBO4

Target: ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (ROBO4))

Andere Bezeichnung: ROBO4 (ROBO4 Produkte)

Synonyme: ECSM4 antikoerper, MRB antikoerper, 1200012D01Rik antikoerper, AI593217 antikoerper, sc:d0823 antikoerper, wu:fa16f09 antikoerper, roundabout guidance receptor 4 antikoerper, roundabout, axon guidance receptor, homolog 4 (Drosophila) antikoerper, ROBO4 antikoerper, Robo4 antikoerper, robo4 antikoerper

Hintergrund: Roundabout homolog 4, also known as magic roundabout and ROBO4 is a member of the immunoglobulin superfamily and ROBO family. ROBO4 is specifically expressed in endothelial cells. It is expressed at sites of angiogenesis in different tumor types. ROBO4 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is the fourth identified member of the roundabout receptor family. It is the only Robo family member expressed in primary endothelial cells and that application of Slit inhibits their migration. ROBO4 is predominantly expressed in embryonic or tumor vascular endothelium and is considered important for vascular development and as a candidate tumor endothelial marker. ROBO4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development. ROBO4 is a receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins. Activating ROBO4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.,ROBO4,ECSM4,MRB,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Extracellular Matrix,Neuroscience,Cardiovascular,Angiogenesis,ROBO4

Molekulargewicht: 75 kDa/98 kDa/107 kDa

Gen-ID: 54538

UniProt: Q8WZ75