MUC1 Antikörper (Mucin 1, Cell Surface Associated)

Details for Product anti-MUC1 Antibody No. ABIN614516
Antigen
  • CA 15-3
  • CD227
  • EMA
  • H23AG
  • KL-6
  • MAM6
  • MCKD1
  • MUC-1
  • MUC-1/SEC
  • MUC-1/X
  • MUC1/ZD
  • PEM
  • PEMT
  • PUM
  • Muc-1
  • mucin 1, cell surface associated
  • mucin 1, transmembrane
  • MUC1
  • Muc1
Reaktivität
Human
1176
176
71
17
7
6
5
4
4
3
3
2
1
Wirt
Maus
791
409
4
3
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser MUC1 Antikörper ist unkonjugiert
60
42
40
40
36
35
11
11
11
11
11
11
11
11
11
11
11
11
11
11
10
10
10
10
10
10
3
3
3
3
3
2
2
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
561
482
457
418
311
280
157
121
57
57
44
40
39
31
26
13
10
6
6
5
4
3
2
2
Optionen
Immunogen MUC1 antibody was raised against high molecular weight (>300kD) glycoprotein from human milk-fat globule molecule.
Klon N-a
Isotyp IgG
Spezifität This antibody reacts to Mucin 1 (MUC1/CA15-3/CA27-29).
Reinigung Protein A chromatography
Plasmids, Primers & others Plasmide, Primers & weitere MUC1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung CD227 / Mucin-1 / MUC1 (MUC1 Antibody Abstract)
Hintergrund This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. Also known as Cancer-associated Antigen 15-3 (CA15-3). Cancer antigen 27.29 (CA27-29), which is expressed on most carcinoma cells, is a soluble form of MUC1.Synonyms: Breast carcinoma-associated antigen DF3, CA 15-3, Carcinoma-associated mucin, DF3, EMA, Episialin, H23AG, MUC-1, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
Gen-ID 4582
NCBI Accession NP_001018016
UniProt P15941
Pathways Negative Regulation of intrinsic apoptotic Signaling
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer PBS, pH 7.4 containing 0.09 % sodium azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Image no. 1 for anti-Mucin 1, Cell Surface Associated (MUC1) antibody (ABIN614516) anti-Mucin 1, Cell Surface Associated (MUC1) antibody (Image 1)
Image no. 2 for anti-Mucin 1, Cell Surface Associated (MUC1) antibody (ABIN614516) anti-Mucin 1, Cell Surface Associated (MUC1) antibody (Image 2)
Image no. 3 for anti-Mucin 1, Cell Surface Associated (MUC1) antibody (ABIN614516) anti-Mucin 1, Cell Surface Associated (MUC1) antibody (Image 3)
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